Abstract: The PTFE-base anti-friction and wear resistance coating which used PTFE as solid lubricant, epoxy resin as binder and MoS₂ as filler was prepared by air spraying method on GCr15 steel substrate. The properties of friction and wear of coating were tested by reciprocating friction and wear tester. The orthogonal test approach was employed to optimize the curing temperature, curing time and the pressure of air spray gun. The results show that the primacy sequence of these factors affected the tribological properties of coating was pressure of air spray gun, curing time, curing temperature. When curing temperature was 120℃, curing time was 60 min and pressure of air spray gun was 0.3 MPa, the average frictional coefficient of coating was 0.106 and wear volume was 0.001 5 mm³ that performed the excellent tribological properties.