Abstract: Based on high temperature creep test of P92 steel pipe bend subjected to in-plane bending the high temperature creep process of the pipe bend with different eccentricity subjected to in-plane bending was simulated by finite element method. The stress and damage at different positions of the bend were analyzed. The relationship model between the eccentricity of pipe bend and the creep lifetime was established and verified by the experimental results. The results show that the creep life of the pipe bend with extrados reduction increased with the increase of eccentricity and had a linear relationship. The creep life of the pipe bend with flank reduction decreased with the increase of eccentricity and showed a slowing trend. The experimental results verified the accuracy of the relationship model and the relationship model could be used to estimate the creep life of pipe bends with uneven wall-thickness subjected to plane bending accurately.