Abstract: Single pass hot compression tests were conducted on 49MnVS3 non-quenched and tempered steel at deformation temperatures of 750-1 000℃ and strain rates of 0.1-50 s^-1, and the Zhou Jihua-Guan Kezhi deformation resistance model was obtained according to the true stress-true strain curves. The average unit rolling pressure of 49MnVS3 non-quenched and tempered steel were calculated by Aiklund model and Zhou Jihua-Guan Kezhi deformation resistance model, respectively, and the calculated results were compared. The results show that the average unit rolling pressures calculated by Aiklund model and Zhou Jihua-Guan Kezhi deformation resistance model increased with the increase of strain. The fluctuation of average unit rolling pressure curve calculated by Aiklund model was relatively small, while the fluctuation by Zhou Jihua-Guan Kezhi deformation resistance model was relatively large. The average unit rolling pressure calculated by Aiklund model was relatively large at low strain rate, and that calculated by Zhou Jihua-Guan Kezhi deformation resistance model was relatively large at high strain rate. When calculating the rolling force by Zhou Jihua-Guan Kezhi deformation resistance model, the data obtained from the thermal simulation test was required, and the model was suitable for controlling model. The Aiklund model calculated the average unit rolling pressure with chemical composition and rolling process parameters; the model was applied relatively widely and suitable for rolling process design.