Abstract: Fatigue test without load-holding and creep-fatigue tests with load-holding at maximum tension/compression strains were conducted on domestic powder metallurgy nickel-based superalloy FGH96 under total strain control at 650℃. The failure life and failure mode of the alloy were studied, and the failure life was compared with that of as-cast nickel-based superalloy GH4169. The results show that the introduced load-holding process reduced the failure life of the FGH96 superalloy. Compared with load-holding at maximum tension strain, the creep damage produced during load-holding at the maximum compression strain was larger, resulting in a shorter failure life. The fatigue failure lives of FGH96 superalloy were higher than those of GH4169 superalloy, and the creep-fatigue failure lives were lower than those of GH4169 superalloy at relatively high strain amplitude (larger than 1.4%), while the opposite was true at relatively low strain amplitude (lower than 1.4%). The fatigue fracture and creep-fatigue fracture of FGH96 superalloy both showed mutiple crack initiation failure characteristics on surface or near surface.