Abstract: Continuous cooling transformation (CCT) curves of X80M pipeline steel ingot were measured by thermal simulation test, and a reasonable cooling rate range was determined. The industrial trial manufacturing test was conducted with a 2 250 mm continuous hot rolling mill. The effects of cooling rate (5, 15, 25℃·s^-1) on the microstructure, mechanical properties and resistance to drop-weight tearing of the X80M strip steel were studied, and the optimal cooling rate was determined. At the optimal cooling rate, the 22 mm thick X80M strip steel was produced in batches, and its microstructure, mechanical properties and resistance to drop-weight tearing were investigated. The results show that when the cooling rate was between 20-30℃·s^-1, a microstructure consisting of acicular ferrite, granular bainite, and dispersed M/A island was obtained, which was beneficial to the performance of the test steel. When the cooling rate increased from 5℃·s^-1 to 25℃·s^-1, the M/A island in the structure of the industrial trial manufactured strip steel became smaller and the distribution was more diffuse; the optimal cooling rate was 25℃·s^-1. The batch-produced X80M strip steel had fine grains and a uniform structure, and its resistance to drop-weight tearing, tensile properties and impact toughness all met the requirements of PetroChina pipeline procurement standards.