Abstract: The finite element model of the honeycomb panel was established, and load-bearing response behavior of honeycomb panel under conditions of flat compression and lateral compression was simulated. The results were verified by experiments. With the finite element model, the influence of welding defects on the bearing capacity of honeycomb panel was studied by introducing the core layer wall debonding and the poor welding defects between panel and core layer. The results show that the honeycomb panel failed by buckling of the core layer under flat compression. Under lateral compression, the honeycomb panel failed by the combination of partial splitting between the panel and core layer, and buckling of the panel. The simulation of the load-displacement curves were in good agreement with the test results under two compression conditions, and the relative errors of the maximun loads were lower than 10%. Under flat compression, the more number of desoldering between the core layer walls the smaller the bearing capacity of brazed aluminum honeycomb panel. Under the lateral compression, the larger the size of the welding defect area, the smaller the maximum bearing capacity of the honeycomb panel, and the easier the structure failure.