Abstract: Inconel600 alloy tube treated by solution and cold rolling cracked longitudinally after repeated cold drawing, and the cracking reason for Inconel600 alloy tube was studied from the aspects of microstructure, non-metallic inclusion, cracking morphology, mechanical properties, processing properties, and solution treatment. The results show that the content of nitrogen was high in the Inconel600 alloy tube, and there were a lot of oxide and nitride formed during smelting process. During cold rolling before cold drawing, the oxide and nitride were chain-like distributed along the rolling direction, and large chain inclusions destroyed the uniform continuity of matrix. During repeated drawing process, stresses were concentrated on the inclusions, leading to microcrack initiation here and propagation, and eventually the alloy tube cracked longitudinally.