Abstract: Tungsten inert gas wire arc additive manufacturing was carried out with the GH4169 superalloy welding wire. The prediction model of the relationship between welding current, welding speed, wire feeding speed and the size of single pass multi-layer welding bead layer width and layer height was established by the quadratic regression general rotation combination scheme, and the calculation was verified by test. The results show that the maximum relative errors of the prediction model of the layer width and the layer height of single pass multi-layer welding bead were 5.22% and 5.82%, respectively, indicating that the established prediction model had high reliability. The effect of welding speed, welding current and wire feeding speed on the forming size of single pass multi-layer welding bead was coupled with each other. The biggest factor affecting the layer width of single pass multi-layer welding bead was the welding current, and the biggest factor affecting the layer height was the wire feeding speed.