Abstract: High-speed milling of GH4169 nickel-based superalloy was carried out at different milling speeds (500-1 000 m·min^-1) and radial milling depths (0.1-0.3 mm). The effects of milling parameters on cutting force, cutting temperature, metamorphic layer and white layer thickness and surface layer hardness were studied. The results show that with the increase of milling speed, the cutting force decreased and the cutting temperature increased. The increase of milling depth resulted in the increase of cutting force and cutting temperature. Under the same milling depth, when the milling speed increased from 500 m·min^-1 to 1 000 m·min^-1, the thickness of the metamorphic layer increased by about 30 μm, the thickness of the white layer increased by about 5 μm, the microhardness of the surface layer increased by about 200 HV, and the depth of the hardened layer increased by about 100 μm. Under the same milling speed, when the milling depth increased by 0.1 mm, the thickness of the metamorphic layer increased by about 30 μm, the thickness of the white layer increased by about 3 μm, the hardness of the surface layer increased by 20 HV, and the depth of the hardened layer increased by about 20 μm.