Abstract: The single-pass hot compression test of 2195 Al-Li alloy was carried out by Geeble-3500 thermal simulator. The hot deformation behavior under the deformation temperature of 360-510 ℃ and strain rate of 0.001-10 s^-1 of the alloy was studied. The constitutive model of hyperbolic sine function based on Zener-Hollomon model was established according to the stress and strain data obtained by tests, and the hot processing map was drawn to obtain the suitable hot working process. The results show that the flow stress of 2195 Al-Li alloy increased with increasing strain rate and decreased with increasing deformation temperature. The alloy had positive strain rate sensitivity. The hot deformation activation energy of 2195 Al-Li alloy was 182.392 kJ·mol^-1. The suitable hot working process of 2195 Al-Li alloy was listed as follows: 410-430 ℃ deformation temperature, less than 0.014 7 s^-1 strain rate and 470-510 ℃ deformation temperature, less than 0.026 9 s^-1 strain rate.