Abstract: With TiC, TiN, WC, Mo powder, Cr₃C₂ as bonded phase raw materials, nickel powder and Cr powder as binders (the total mass fraction was 25%, and the mass fraction of Cr powder was 0, 2.5%, 5.0%, 7.5%), different Ti(C, N)-based cermets were prepared by vacuum sintering process. The effect of Cr addition on the microstructure, mechanical properties and antioxidant properties of the cermet was investigated. The results show that the grains of Ti (C, N)-based cermets with different Cr content all exhibited the core-ring structure, whose core phase was Ti (C, N) and ring phase was (Ti, W, Mo, Cr) (C, N) multivariate solid solution. With the increase of Cr addition, the cermet grain size became significantly larger, and the homogeneity of the ring phase deteriorated. With the increase of Cr addition, the hardness of the cermet increased, the flexural strength decreased, and the fracture toughness first increased and then decreased. When the mass fraction of Cr in the binder phase was 5.0%, the comprehensive mechanical properties of the cermet were the best with the flexural strength, hardness, and fracture toughness of 1 829 MPa, 90.5 HRA, and 11.57 MPa · m^1/2, respectively. When the mass fraction of Cr in the binder phase was 5.0%, the oxidation mass increase per unit area of the cermet was lower than that without Cr addition, and the denser oxide film containing NiCr₂O₄ and CrMoO₄ was formed on the cerment surface during the oxidation process. The dense oxide film effectively impeded the further diffusion of the oxygen element and enhanced the antioxidant performance of the substrate.