Abstract: FeCoCrNiAl_0.5Ti_0.5 high entropy alloy powder was prepared by mechanical alloying, and then high entropy alloy coating was prepared by plasma cladding. The microstructure of the high entropy alloy powder was studied after mechanical alloying, and the microstructure, hardness and wear resistance of the high entropy alloy coating were analyzed. The results show that the FeCoCrNiAl_0.5Ti_0.5 high entropy alloy powder with two-phase solid solution structure of body-centered cubic and face-centered cubic structures was formed after mechanical alloying, and the particle size was 2–4 μm. The cladded entropy alloy coating still maintained the two-phase solid solution structure, and had no obvious pores, cracks and other defects. The typical cladding microstructure of cellular crystals→dendritic crystals→equiaxed crystals were formed from cladding interface to coating surface in the high entropy alloy coating in sequence. The average microhardness of the high entropy alloy coating was 616.6 HV, which was 1.46 times that of NM400 steel. Under the same wear conditions, the wear quality loss of the high entropy coating was 48% that of NM400 steel, and the wear mechanism was mainly abrasive wear; the high entropy coating had relatively excellent wear resistance.