Abstract: The surface of the rolled Ti-6Al-4V alloy was repaired by laser cladding of Ti-10V-2Al-3Fe alloy powder. The samples after laser cladding were subjected to annealing at 650 ℃ for 2 h and to solution at 750 ℃ for 2 h + aging at 510 ℃ for 8 h separately. The influence of the heat treatment process on the microstructure, hardness and tensile properties of different regions of the samples was studied. The results show that the microstructure of the as-deposited cladding layer was composed of original columnar β grains and net-like α phases within the β grains, and the microstructure of the heat-affected zone was supersaturated acicular martensite. After annealing, a part of the net-like structures in cladding layer grew, some lamellar α phases transformed into equiaxed α phases; the martensite in the heat-affected zone decreased, forming dispersed (α+β) phases; α equiaxed grains appeared in the substrate with an original structure composed of lamellar α phase extension grains and β grain boundaries. Compared with those in the annealed state, the partial net-like structure of the laser cladding layer in the solution aged state further grew, and more layers of α phase transformed into equiaxed α phase; the martensite in the heat-affected zone further decreased, and more α equiaxed crystals appeared in the substrate. The annealing and solution aging treatment decreased the hardness of the laser cladding layer, but had little effect on the overall hardness of the substrate and the heat-affected zone. After annealing, the tensile strength and yield strength of the substrate and the cladding layer decreased, while the percentage elongation after fracture increased. The solution aging treatment made the strength of the substrate decrease while the percentage elongation after fracture increase, and made the strength and the percentage elongation after fracture of the cladding layer increase. The comprehensive mechanical properties of the sample after 750 ℃× 2 h solid solution and 500 ℃× 8 h aging were the best. The hardness of the substrate and laser cladding layer was 349, 373 HV, the tensile strength was 888,1 003 MPa, and the percentage elongation after fracture was 22.1% and 20.9%, respectively.