Abstract: The Co-based alloy cladding coating was successfully fabricated on the surface of NAK80 mold steel by laser cladding technology. The microstructure of the coating was analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD). The property of friction and wear, and the wear mechanism were studied by the dry sliding friction test. The morphology of wear samples were measured by 3D surface profilometer. The results show that the cladding coating was mainly composed of Cr23C6, Co3Mo2Si, MoC, FeCr and γ-Co. The plane crystal in the interface of the coating and the substrate, cellular dendrite at the central zone and reticular equiaxed crystal near top surface were observed in the cladding coating. The microhardness and wear resistance of NAK80 mold steel surface were improved noticeably by laser cladding technology. Compared with NAK80 mold steel, the average friction coefficient of the cladding coating decreased by about 34%, and the wear rate reduced by about 91.3%. The wear mechanism for the laser cladding coating was adhesive wear and slight micro-cutting.