Abstract: Taking X80 pipeline steel as research object and simulated solution of Jiangxi Zhangshu area soil as test environment, the effects of applied potential, strain rate and the interaction of above factors on stress corrosion susceptibility of X80 pipeline steel were studied. The results show that the tested steel was very sensitive to stress corrosion cracking (SCC) at medium strain rates and cathodic potentials. Under anodic potential condition, the material interchange induced by strain rate had small effect on SCC process and the SCC susceptibility was relatively low. In cathodic potential area, hydrogen evolution reaction happened on the tested steel , the interchange between bulk solution and the solution inside crack and the interchange between the solution inside crack and the metal atoms in crack-tip were sufficient at medium strain rates, and the trend of the tested steel suffering hydrogen induced cracking increased and the SCC susceptibility was higher.