Abstract: A fretting fatigue test apparatus was self-designed and manufactured to carry out the fretting fatigue test for specimens of anisotropic nickel-based alloys DD3 and DZ125 contacted with pad of powder metallurgy superalloy FGH95. The fractures initiating cracks on contact zone were observed, and the effects of axial and normal stress on fretting fatigue life and fretting fatigue parameters, such as maximum equivalent stress(Von-Mises equivalent stress), slip amplitude and normal strain amplitude, were analyzed. The results show that the fretting fatigue life reduce with an increase in axial stress while keeping normal stress at a constant value. Also, the influence of normal stress is not obvious on fretting fatigue life as the effects of axial stress. The maximum equivalent stress and normal strain amplitude are affected by normal stress and axial stress, while the slip amplitude is only affected by axial stress.