Abstract: The effects of catalysts, materials,reaction temperature, hard segment content and R value on the synthesis of polyether type thermoplastic polyurethane elastomer(TPU) and mechanical property of synthetic TPU were investigated. Results show catalytic effect of three of catalyst, Bi-8, 100-Ag and TPT, rose up when the initial reaction temperature increased. With the increase of hard segment content, the hardness, tensile strength, set out modulus, tear strength of PTMEG-1000 and PTMEG-1800 TPU improved, but breaking elongation decreased. With the increase of R value, mechanical properties of TPU improved. TPU synthesized using PTMEG-1000 exhibited better the comprehensive property than that using PTMEG-1800. Compared with the product of Noveon, TPU synthesized using PTMGE-1000 had better mechanical property in 100% elongation, 300% elongation modulus and tear strength, but worse in breaking elongation and tensile strength.