Abstract: Nickel plated Y2O3 powders were prepared by surface modifying and chemical nickel-plating technology, and was added into nickel-based high temperature alloy powders to prepare oxide dispersion strengthened (ODS) nickel-based high temperature alloy by mechanical alloying and vacuum sintering process, and the effects nickel plating and Y2O3 phase content on microstructure, relative density and tensile strength of the alloy were studied. The results show that nickel plating process improved the segregation of black Y2O3 phase with flake and net-work, and increased the optimal adding amount of Y2O3 powders, relative density and tensile strength from 1.5wt%, 95.32%, 639 MPa, before nickel plating, to 5wt%, 97.45%, 725 MPa.