Abstract: AlCrFeCoNiCu high-entropy alloy was prepared in a vacuum arc furnace, and the microstructure and properties of as-cast and annealed alloys were studied. The results show that the as-cast microstructure of the alloy was dendritic, and it was comprised of solides with face-centered cubic(FCC) structure and body-centered cubic(BCC) structure. The interdendrite phase enriched Cu appeared net shape with the increase of the annealing temperature. The intermetallic compounds began to being found in the alloy after annealing at 600 ℃, and the microstructure was not complete solide solution. The hardness of as-cast alloy was higher than annealed alloys. The compressive strength of as-cast alloy was 1.71 GPa and that of the alloy annealed at 800 ℃ was 1.63 GPa, and their compressive fractures all were brittle fracture.